For the West Ham goalkeeper is the first call-up for senior National Team and could make his first cap in upcoming fixtures.
Spain will warm up before their Russia 2018 FIFA World Cup qualifiers with a friendly against Belgium. Spain travel to face Belgium in Brussels on Thrusday 1 September, with matters getting under way at the King Baudouin Stadium at 8.45pm GMT.
Lopetegui's men then return to Spain, where they face Liechtenstein at Reino de Leon stadium on Monday 5 September, with a kick-off time of 8:45pm GMT.
The full call-up list is as follows:
- Goalkeepers: David de Gea (Manchester United), Pepe Reina (Nápoles), Adrián San Miguel (West Ham).
- Defenders: Marc Bartra (Borussia), Jordi Alba (Barcelona), Gerard Piqué (Barcelona), César Azpilicueta (Chelsea), Sergio Ramos (Real Madrid), Dani Carvajal (Real Madrid), Sergi Roberto (Barcelona), Javi Martínez (Bayern).
- Midfielders: Sergio Busquets (Barcelona), David Silva (Manchester City), Thiago Alcántara (Bayern), Saúl Ñíguez (Atlético Madrid), Koke (Atlético Madrid), Juan Mata (Manchester United), Marco Asensio (Real Madrid).
- Forwards: Alvaro Morata (Real Madrid), Lucas Vázquez (Real Madrid), Nolito (Manchester City), Paco Alcácer (Valencia), Diego Costa (Chelsea), Vitolo (Sevilla).